How should I respond when my cat hisses at me? Why is my cat 'angry' at me?

Quick answer

A "hiss!" is a strong defensive signal that means your cat is extremely scared or anxious and is warning that they'll attack if you get any closer. When your cat hisses, the wisest response is to avoid direct eye contact, immediately stop paying attention, and step away to give them their own space to calm down on their own. Yelling or scolding will only damage your relationship.